Sensor Augmented Insulin Therapy

Sensor Augmented - INIT

 

What is Sensor Augmented Insulin Pump Therapy?


The insulin pump acts as the receiver of the CGM data which is sent wirelessly from the sensor by the transmitter.


What is Sensor Augmented Insulin Pump Therapy?


 

Sensor Augmented - PAGE 2

What is the scientific evidence?

STAR 3 Study

30 Sites (U.S. and Canada)

• 485 type 1 patients   • 1 year study   • 6 month follow-up
Bergenstal RM, Tamborlane WV, Ahmann A, et. al. N Engl J Med. Doi: 10. 1056/NEJMoa1002853
 

What is the scientific evidence?

STAR 3 Study: Primary Endpoint (All Patients)

The Sensor Augmented Pump (SAP) group achieved a greater A1C reduction vs. the Multiple Daily Injections (MDI) group at 3 months and sustained it over 12 months.

Bergenstal RM, Tamborlane WV, Ahmann A, et. al. N Engl J Med. Doi: 10. 1056/NEJMoa1002853
 

What is the scientific evidence?

STAR 3 Study: A1C Reduction Correlates to Increased Sensor Use

  • The majority of patients used sensors ≥61% of the time
  • Patients who used sensors ≥81% of the time reduced their mean A1C by 1.2% at 1 year vs. baseline
Bergenstal RM, Tamborlane WV, Ahmann A, et. al. N Engl J Med. Doi: 10. 1056/NEJMoa1002853
 

What is the scientific evidence?

STAR 3 Study: Cumulative Events at 1 Year (All Patients)

No significant difference in severe hypoglycemia, DKA and weight change.

Bergenstal RM, Tamborlane WV, Ahmann A, et. al. N Engl J Med. Doi: 10. 1056/NEJMoa1002853
 

What is the scientific evidence?

STAR 3 Conclusions

Sensor augmented insulin pump therapy resulted in:

  • Overall A1C (mean) reduction 4x greater than MDI (0.8% v. 0.2%) for adults and pediatric patients from baseline to one year without an increase in severe hypoglycemia
Sensor Augmented Pump (SAP): from 8.3% to 7.5%
Multiple Daily Injections (MDI): from 8.3% to 8.1%

  • 1.0% AIC (mean) reduction in adults from baseline to one year
  • Patients wearing sensors ≥81% of the time reduced their mean A1C by 1.2% (reduction from baseline to one year)
  • Glycemic improvements were seen early (3 months) and were sustained at one year

Bergenstal RM, Tamborlane WV, Ahmann A, et. al. N Engl J Med. Doi: 10. 1056/NEJMoa1002853